The purpose of this study is to determine safety and efficacy of clevudine 10 mg qd for 24 weeks after completion of 24-week treatment with clevudine 30 mg qd with 12 weeks follow-up period
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Efficacy:change from baseline in HBV DNA; Safety: clinically measured adverse events, abnormality of laboratory tests and abnormality of vital signs, ECG.
Efficacy:; Proportion of patients with HBV DNA below the assay Limit of Detection; Proportion of patients with HBeAg loss and/or seroconversion (HBeAg loss and HBeAb gain); Proportion of ALT normalization
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Pusan National University Hospital
Ami-dong, Seo-gu, Busan, South Korea
Kosin Medical Center
Amnam-dong, Seo-gu, Busan, South Korea
Pusan Paik Hospital
Gaegeum-dong, Busan, South Korea
Chungnam National University Hospital
Daesa-dong, Jung-gu, Daechon, South Korea
Yeungnam University Medical Center
Daemyoung-dong, Nam-gu, Daegu, South Korea
Keimyumg University Dongsan Medical Center
Jung-gu,, Daegu, South Korea
Kyungpook National University Medical Hospital
Jung-gu, Daegu, South Korea
Korea University Guro Hospital
Seoul, Guro-gu, South Korea
Chonnam National University Hospital
Hak-1-dong, Dong-gu, Gwangju, South Korea
St. Mercy's Hospital
Bupyoung-dong, Bupyoung-gu, Incheon, South Korea
...and 22 more locations