The purpose of this study is to determine the safety and antiviral activity of Clevudine, when retreated to patients previously treated with Clevudine
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
33
Korea University Guro Hospital
Seoul, Guro-gu, South Korea
Seoul National University Hospital
Seoul, Jongno-Gu, South Korea
Yongdong Severance Hospital
Dogok-dong, Kangnam-gu, Seoul, South Korea
Samsung Medical Center
Ilwon-dong, Songpa-gu, Seoul, South Korea
Antiviral activity- Change from baseline in HBV DNA (log10)
Safety- Laboratory tests, Adverse Events, Vital Signs, ECG
Antiviral activity- Proportion of patients with HBV DNA below the assay Limit of Detection(<4,700 copies/mL by Digene Hybrid Capture II)
Biochemical improvement (ALT normalization)
Serology: Proportion of patients with HBeAg loss,Seroconversion rate (HBeAg loss and anti-HBe gain)
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Ehwa Womans University Mokdong Hospital
Mok-dong, Yangcheon-gu, Seoul, South Korea
Seoul Asan Medical Center
Pungnap-dong, Kangnam-gu, Seoul, South Korea
Asan Medical Center
P’ungnabi-dong, Songpa-Gu, Seoul, South Korea