Molecular Epidemiology of Benzene-exposed Workers.

University of Colorado, Denver2,000 enrolled

Overview

The purpose of this study is to investigate the health effects of benzene exposure in workers in Shanghai, China.

The purpose of this study is to investigate the dose-response relationship between benzene exposure and blood diseases in Shanghai workers and to characterize genetic polymorphisms that are associated with increased risk of developing benzene hematotoxicity.

Study Type

OBSERVATIONAL

Enrollment

2,000

Conditions

Hematologic Diseases

Interventions

Shanghai workersOTHER

Eligibility

Sex: ALLMin age: 18 YearsMax age: 67 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Worked for at least one year in a monitored environment Have at least one physical examination recorded \- Exclusion Criteria: History of cancer, radiation exposure, chemotherapy \-

Locations (1)

Joint Sino-US Clinical and Molecular Laboratory (JCML)

Shanghai, China

Outcomes

Primary Outcomes

Investigate the dose-response relationship between benzene exposure and blood diseases in Shanghai workers.

Investigate the dose-response relationship between benzene exposure and blood diseases in Shanghai workers

Time frame: August 2003 - December 2009

Secondary Outcomes

Characterize genetic polymorphisms that are associated with increased risk of developing benzene hematotoxicity.

Time frame: August 2003 - December 2009

Data from ClinicalTrials.gov

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