The use of CNIs (CSA or FK) as primary immunosuppressive drugs after pediatric liver transplantation is one of the main causes of chronic kidney disease in these patients in the long term. The study objective is the evaluation of safety of a modification in immunosuppression from a dual-immunosuppression (CSA or FK plus steroids) to a triple immunosuppression (MMF plus CSA (reduced dosage) plus steroids.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
25
Hannover medical School
Hanover, Germany
safety of a triple immunosuppression (MMF/CSA/Steroids)regarding the number of acute rejections
Time frame: 1, 3, 6, 9, 12, 24 month
incidence of chronic kidney disease
Time frame: 12, 24 month
incidence of infections
Time frame: 1, 3, 6, 9, 12, 24 month
incidence of ptld (post transplant lymphoproliferative disease)
Time frame: 1, 3, 6, 9, 12, 24 month
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