Topical steroid use may lead to skin deterioration and spider veins. This study will examine long-term management of atopic dermatitis (AD) over 12 months with pimecrolimus cream 1% and its effect on skin reconstitution of steroid-damaged skin and disease control.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
41
Pimecrolimus cream 1% bid, as needed
Novartis
Novartis, Germany
• Decrease of the Dermatophot (a combination of a dermatoscope and a camera) score on skin deterioration and spider veins from baseline to end of the study
Time frame: 48 weeks
• Epidermal thickness by optical coherence tomography at selected investigational centers
Time frame: 48 weeks
Skin thickness by ultrasound at selected investigational centers
Time frame: 48 weeks
Epidermal thickness by 3mm punch biopsies (optional)
Time frame: 48 weeks
Skin metabolism by suction blisters.
Time frame: 48 weeks
Investigator's Global Assessment (IGA)
Time frame: 48 weeks
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