Evaluate the systolic blood pressure lowering effect of aliskiren 150mg and 300mg compared to ramipril 5mg and 10mg in elderly patients with essential systolic hypertension.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
901
Novartis Pharmaceuticals
East Hanover, New Jersey, United States
Change From Baseline in Mean Sitting Systolic Blood Pressure to Week 12
Time frame: Baseline and Week 12
Percentage of Patients With Cough
Time frame: Weeks 12 and 36
Percentage of Patients Achieving Blood Pressure Control at Weeks 12 and 36 Endpoints
Blood pressure control is defined as a mean sitting blood pressure \< 140/90 mm Hg
Time frame: Weeks 12 and 36
Change From Baseline in the Mean Sitting Diastolic Blood Pressure to Week 36
Time frame: Baseline and week 36
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Amlodipine 5 mg or 10 mg tablets taken orally, once a day in the morning