A Trial of Erlotinib + Radiotherapy for Cutaneous Squamous Cell Carcinoma

Inclusion Criteria: * Histologically proven primary or recurrent squamous cell carcinoma arising from the lip or skin of the face, ear, scalp or neck. * Participants must meet one of the four criteria: * 1\. T4 cutaneous SCC as determined by physical exam, imaging studies, prior resections or biopsy. T4 disease is defined as tumor that invades deep extradermal structures such as cartilage, skeletal muscle (e.g., muscles of facial expression), parotid gland or bone.Patients with a T2 or greater squamous cell carcinoma of the lower lip who will require post operative radiation will be allowed. * 2\. Histologically proven regional lymph node involvement (N1 disease). Fine needle aspiration or biopsy can be used to demonstrate the presence of lymphatic spread. * 3\. Histologically proven parotid gland metastasis. Fine needle aspiration or biopsy can be used to demonstrate the presence of regional spread. Includes delayed regional metastasis; primary scalp or other skin lesion treated within 36 months that would drain into the involved parotid. * 4\. Patients who following surgical resection of the primary are found to have histologically positive lymph nodes (N1). Includes delayed regional metastasis; primary lip or cutaneous lesion treated within 36 months that would drain into the involved nodal basin. * Age \> 19 years * Tumors must be considered surgically resectable.(Patients may be enrolled after surgery is completed as long as Erlotinib therapy and concurrent radiation is started within 8 weeks of surgical resection.) * Required laboratory data obtained prior to beginning treatment: WBC \> 1,500/ml; Platelets \> 90,000; serum creatinine ≤ 2.0 mg/dl * The patient may have had a prior non-cutaneous malignancy, but must be two years from treatment. * Performance status of ≤ 2 (ECOG scale) and life expectancy ≥ 12 months. * The patients must agree to use effective contraception if there is the potential for procreativity. Contraception must be conducted for at least 3 months following the study. * Patients must sign informed consent Exclusion Criteria: * The patient has received prior radiation therapy to the head and neck. * The patient is pregnant or lactating * Patients with a prior history of head and neck mucosal cancers. * Psychological condition that renders the patient unable to understand the informed consent.