SPL7013 Gel - Male Tolerance Study

Inclusion Criteria: * Provision of written informed consent * Healthy males aged 18 years or older * HIV negative * Reports vaginal intercourse in the past 12 months * Agrees to abstain from vaginal, anal (receptive and insertive) and oral sexual intercourse, and agrees to refrain from masturbation during the 7 days of product use until after the End-of-Treatment (Day 7) study visit Exclusion Criteria: * Known or suspected allergy to any component of the study products or similar ingredients in other products * History of significant drug reaction or allergy * Recent history (within 12 months) or presence at screening of contact dermatitis or other dermatological condition * Recent history (within three months of Screening) of a sexually transmitted infection (STI) * Current signs or symptoms of UTI and/or STI at Screening or Baseline * Positive urine leukocyte esterase test (≥ trace) * Biochemical and/or haematological parameters outside the laboratory's normal reference ranges at Screening * Evidence of genital piercing, ulceration, genital dermatoses, tinea cruris or other dermatological condition of the genitalia or upper thighs * Genital pain or discomfort at Screening or Baseline * Any other abnormal finding on physical examination or other medical condition