Glucose Control in Open Heart Surgery

University of Sao Paulo98 enrolled

Overview

The purpose of the study is to seek if there is difference to state glucose level in 80-120mg/dl or 200mg/dl in patients submitted to open heart surgery

Hyperglycaemia in the intensive care unit and perioperative period has been accused to be one of the causes of worse clinical outcome. It is known that in open heart surgeries the glucose level must be set less than 200mg/dl, but new trials had set the glucose level lower than that: 140mg/dl in some studies and even lower (80-110mg/dl). Our trial had the intention to seek if there is difference setting glucose level in 2 different ones would modifies clinical outcome.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Hyperglycaemia During Perioperative Period Heart Valve Diseases Ventricular Dysfunction

Interventions

human regular insulinDRUG

Eligibility

Sex: ALLMin age: 21 Years

Medical Language ↔ Plain English

Inclusion Criteria: * adult more than 21 years old * open heart surgery with cardiopulmonary bypass Exclusion Criteria: * renal dysfunction * reoperation * use of inotropic support * neurological dysfunction * chronic pulmonary obstructive disease * emergency or urgency

Locations (1)

Heart Institute, Hospital of Clinics, São Paulo University Medical School

São Paulo, São Paulo, Brazil

Outcomes

Primary Outcomes

Duration of intubation

ICU length

Blood transfusion

Infection rate

Renal dysfunction

Neurological dysfunction

Hospital length

Mortality

Secondary Outcomes

Length of surgery

Length of cardiopulmonary bypass

Physical status

EuroSCORE

Parsonnet

Canadian Multicenter index

Data from ClinicalTrials.gov

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