Oral Colchicine Combined With Intravitreal Infusion of Dexamethasone, LMW Heparin and 5-FU for Management of Proliferative Vitreoretinopathy (PVR)

Shahid Beheshti University of Medical Sciences

Overview

To evaluate the efficacy of oral colchicine combined with intraoperative infusion of dexamethasone, low molecular weight heparin and 5-FU during vitrectomy for management of established proliferative vitreoretinopathy (PVR)

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Conditions

Proliferative Vitreoretinopathy

Interventions

oral colchicine, dexamethasone, low molecular weight heparin, 5-FUDRUG

placeboDRUG

Eligibility

Sex: MALEMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Cases with rhegmatogenous retinal detachment complicated by PVR grade C Exclusion Criteria: * History of pars plana vitrectomy for PVR grade C * History of silicone oil injection * History of ocular trauma * Diabetic retinopathy * Glaucoma * Giant retinal tear

Locations (1)

Hamid Ahmadieh, MD

Tehran, Tehran Province, Iran

RECRUITING

Outcomes

Primary Outcomes

Retinal reattachment rate

Secondary Outcomes

PVR recurrence,

macular pucker,

reoperation,

ocular hypotony,

visual acuity

Central Contacts

Hamid Ahmadieh, MD

CONTACT

+98 21 22585952 hahmadieh@hotmail.com

Data from ClinicalTrials.gov

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