Effect of Adjunctive Treatment With Arestin on the Subgingival Microflora in Patients With Moderate to Advanced Periodontitis

Inclusion Criteria: * Generalized moderate to advanced chronic periodontitis, five sites with probing depths of \>5 mm in 5 non-adjacent interproximal spaces, excluding the distal of terminal teeth, at least 16 teeth excluding 3rd molars and implants Exclusion Criteria: * Allergy to tetracycline * Subjects with aggressive periodontitis * Acute necrotizing ulcerative gingivitis, or gross decay * Systemic conditions which could influence the course of periodontal disease (i.e, diabetes, autoimmune disease, etc) * Individuals requiring prophylactic antibiotics * Any periodontal therapy within the previous 3 months (excluding maintenance therapy) * Systemic or local antibiotic therapy within three months