Bone Microstructure in Nasal Salmon Calcitonin Treated Postmenopausal Women

Inclusion Criteria: * Women between age 45-70 * Natural or surgical menopause ≥ 1 year * T-Score between 0.0 and -2.49 (spine or proximal femur - total or femoral neck measured by DXA) Exclusion Criteria: * Osteoporosis (T-score ≤ -2.5 in spine or proximal femur - total or femoral neck, measured by DXA) * Severe vertebral fracture, as identified by screening DXA assessment * Any history of metabolic disease, which could affect bone metabolism: hyperparathyroidism, osteogenesis imperfecta, Paget's disease, osteomalacia * Thyroid disease (if receiving thyroid hormone replacement, the patients must be euthyroid, and on a stable dose of thyroid hormone) * Impaired renal function (estimated GFR\<30 ml/min) * History of previous or active malignancy of any organ system, treated or not treated within the past 5 years. * History of corticosteroids treatments during 6 months or more, daily dosage \>5 mg . * BMI \< 18 or \>30. * Treatments with estrogens, SERMs, tibolone, calcitonin, strontium ranelate, teriparatide or PTH, oral or iv bisphosphonates in the previous year.