To Compare Intravitreal Clindamycin & Dexamethasone With Classic Treatment of Toxoplasmic Retinochoroiditis

Shahid Beheshti University of Medical Sciences

Overview

Toxoplasmosis, an intra cellular parasite, is a very important cause of chorioretinitis. The goal of treatment is arresting multiplication of the parasite in its inflammatory active phase. In this study the investigators try to compare the efficacy of the classic regimen (Pyrimethamine-Sulfadiazine + Prednisolon) with intravitreal Clindamycin \& Dexamethasone.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Conditions

Chorioretinitis

Interventions

pyrimethamine-sulfadiazine + prednisoloneDRUG

Administration of pyrimethamine-sulfadiazine + prednisolone

Clindamycin+DexamethasoneDRUG

Intravitreal injection of Clindamycin+Dexamethasone

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with Toxoplasmic chorioretinitis * Location of the lesion within zone I of the retina or a lesion greater than 2DD with 3+-4+ vitreous inflammation in zone II or III * No allergic history to the used drugs * No any other diseases Exclusion Criteria: * Any allergic reaction to the used medications * One eyed patients * Partially treated patients

Locations (1)

Ophthalmic Research Center

Tehran, Tehran Province, Iran

Data from ClinicalTrials.gov

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