Study of Brinzolamide and Timolol When Added to Travoprost in Primary Open-angle Glaucoma or Ocular Hypertension

Alcon Research245 enrolled

Overview

The purpose of the study is to compare the efficacy and safety of Timolol 0.5% solution to Brinzolamide 1% each given twice daily when added to Travoprost 0.004% given each evening.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

245

Conditions

Primary Open-angle Glaucoma Ocular Hypertension Pigment Dispersion Glaucoma

Interventions

Brinzolamide 1% added to Travoprost 0.004%DRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who are treated with any prostaglandin analogue monotherapy (excluding unoprostone) and who have an intraocular pressure between 19 and 32 mmHg at 08:00 hours. Exclusion Criteria: * Under 18 years

Locations (1)

Mainz Site

Mainz, Germany

Outcomes

Primary Outcomes

Mean diurnal intraocular pressure at month 3

Secondary Outcomes

Individual intraocular pressures measured at 08:00, 12:00 and 16:00 at month 3.

Reduction from baseline in mean diurnal intraocular pressure and individual timepoints.

Visual acuity, Slit lamp biomicroscopy and adverse events during 3 months.

Data from ClinicalTrials.gov

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