Individual Versus Standard Follicle Stimulating Hormone Dose for Controlled Ovarian Stimulation and Insemination

Nina la Cour Freiesleben234 enrolled

Overview

The purpose of this study is to test if recombinant follicle stimulating hormone (rFSH) given in individual doses, according to a nomogram we have constructed based on our results from a previous study, results in more patients maturing 2-3 follicles compared to standard dose.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

234

Conditions

Infertility

Interventions

rFSH drug doseDRUG

"Individual" rFSH dose (50, 75 or 100 IU rFSH/day)

"Standard" rFSH doseDRUG

"Standard" rFSH dose was 75 IU/day

Eligibility

Sex: FEMALEMin age: 25 YearsMax age: 39 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age between 25-39 years * First stimulation with rFSH only * Indication for intrauterine insemination with standard rFSH starting dose * Regular menstrual bleeding with a cycle between 21-35 days * Two ovaries * Bilateral tuba patency * Semen analysis must be sufficient for insemination according to the diagnostic analysis. Exclusion Criteria: * More than three former stimulated intrauterine insemination cycles

Locations (1)

The Fertility Clinic, dep.4071, Copenhagen University Hospital, Rigshospitalet

Copenhagen East, Denmark

Outcomes

Primary Outcomes

Number of mature follicles in the study and control group.

Secondary Outcomes

Number of cycles where the rFSH dose is changed.

Number of cycles cancelled or converted to in vitro fertilisation.

Pregnancy rate.

Time frame: October 2008

Data from ClinicalTrials.gov

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