Removal of Protein Bound Uremic Toxins by Modified Plasma Separation and Adsorption Combined With Hemodialysis

Rigshospitalet, Denmark10 enrolled

Overview

The aim of this study is to examine removal of protein bound uremic substances by mFPSA in chronic hemodialysis patients. mFPSA is an extracorporal blood purification system developed for detoxification in acute liver failure by removal of protein bound as well as water soluble substances.

Measurements of uremic protein bound substances before and after mFPSA and a preceding routine hemodialysis session.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Uremia

Interventions

mFPSA treatmentPROCEDURE

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Over the age of 18 * Anuria * Chronic hemodialysis dependence Exclusion Criteria: * No present history of bleeding episodes * Cardiac diseases

Locations (1)

Rigshospitalet

Copenhagen, Copenhagen, Denmark

RECRUITING

Outcomes

Primary Outcomes

Blood pressure

Safety serological parameters

Concentrations of protein bound uremic toxins

Secondary Outcomes

Bleeding episodes

Central Contacts

Mette B Damholt, MD,Ph.d.

CONTACT

+45 35453545 damholt@dadlnet.dk

Soren D Ladefoged, MD

CONTACT

+45 35453545 SOERENRH04736LADEFOGED@rh.dk

Data from ClinicalTrials.gov

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