Computer-Assisted Total Knee Replacement Kinematics: DePuy Sigma Posterior Cruciate Substituting Knee and the DePuy Sigma RP Rotating Platform Knee

Queen's University91 enrolled

Overview

Primary Research Questions: 1. Do patients with knee osteoarthritis (OA) who undergo total knee replacement with a Sigma rotating platform have better clinical outcomes at 2 years post surgery (i.e. quality of life, function, range of motion) than similar patients who undergo total knee arthroplasty (TKA) using the Sigma fixed bearing knee? 2. Do patients with knee OA who undergo TKA with a Sigma rotating platform have different knee kinetics and kinematics as measured by gait analysis than similar patients who undergo TKA using the Sigma fixed bearing knee? 3. Do patients with knee OA who undergo TKA with or without computer assistance have better clinical outcomes at two years following surgery (quality of life, function, range of motion)? 4. Do patients with knee OA who undergo TKA with or without computer assistance have different knee kinematics and kinetics as measured by gait analysis?

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Osteoarthritis, Knee

Interventions

Eligibility

Sex: ALLMin age: 45 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age 45-75 years * Undergoing primary total knee arthroplasty * Clinically significant osteoarthritic degeneration Exclusion Criteria: * Active articular infections * Bilateral knee replacement (simultaneous) * Previous joint infections * Significant concurrent ipsilateral hip osteoarthritis * Chronic pain syndrome requiring medications for control * History of chemical addiction * Significant spinal stenosis, significant symptomatic sciatica * Patients who are unlikely to comply with, participate in, or return for follow-up visits as described in the protocol * Osteomyelitis, septicemia or other infections that may spread to other areas of the body * Highly communicable diseases, immuno-compromising conditions and/or conditions that may limit follow-up (eg. AIDS, active tuberculosis, venereal disease, active hepatitis, neoplastic disease) * Decreased mental comprehension and literacy * Prior high tibial osteotomy * Prior patellectomy * Rheumatoid arthritis * Pregnancy

Locations (3)

University of Manitoba

Winnipeg, Manitoba, Canada

Kingston General Hospital

Kingston, Ontario, Canada

London Health Sciences Center

London, Ontario, Canada

Computer-Assisted Total Knee Replacement Kinematics: DePuy Sigma Posterior Cruciate Substituting Knee and the DePuy Sigma RP Rotating Platform Knee

Overview

Conditions

Interventions

Eligibility

Locations (3)

Outcomes

Primary Outcomes

Secondary Outcomes