Catechin Mouth-washing for Removal of Intraoral Bacteria

Masahiro Morikawa36 enrolled

Overview

The Purpose of this study is to evaluate the effects of catechin mouth-washing on the removal of intraoral bacteria in the elderly

Catechins are the major components of tea flavonoids and recent in vitro experimental studies have revealed that tea catechin extracts induce bactericidal effects. However, a limited number of studies have been conducted on the clinical effects of tea catechin against bacterial infection and also the effects in the elderly is unclear. Based on these backgrounds, we designed a prospective randomized controlled study to evaluate the effects of catechin mouth washing on oral pathogenic bacterial detected in the elderly.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Elderly

Interventions

catechin extractsDIETARY_SUPPLEMENT

catechin extracts solution

Eligibility

Sex: ALLMin age: 65 YearsMax age: 95 Years

Medical Language ↔ Plain English

Inclusion Criteria: * aged over 65 years * detected oral pathogenic bacterium and revalidated during the wash-out period * without antibacterial medicine, other mouth-washing remedies during the study * Obtained written informed consent before participation Exclusion Criteria: * possessing some infectious diseases in need of therapy * possessing tea or catechin allergy * diagnosed as inadequate for other reasons to participate the study by principal investigator

Locations (1)

White cross nursing home

Higashimurayama, Tokyo, Japan

Outcomes

Primary Outcomes

Removal of intraoral pathogenic bacteria identified before the study

Time frame: After intervention

Secondary Outcomes

Reduction of intraoral bacteria after the study

Time frame: After intervention

Data from ClinicalTrials.gov

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