Nordic Everolimus (Certican) Trial in Heart and Lung Transplantation

Inclusion criteria: * Patients who have undergone a heart or lung transplantation more than 12 months ago. * Patients receiving Neoral® or Prograf®. * Patients with a measured or calculated glomerular filtration rate (GFR) \> 20 and \< 70 mL/min/1.73m\^2. For patients with a GFR \> 60 and \< 70 mL/min/1.73m\^2, a deteriorated renal function since the time of transplantation must be documented by at least one post-transplant GFR level that is \> 10% above the GFR level at the time of inclusion. * Patients willing and capable of giving written informed consent for study participation and able to participate in the study for 12 months. * Females of potential childbearing age must have a negative serum pregnancy test within 7 days prior to enrollment. Effective contraception must be used during the trial and for 6 weeks following discontinuation of the study medication, even where there has been a history of infertility. Exclusion criteria: * Patients who are recipients of multiple organ transplants. * Patients with measured GFR \< 20 mL/min/1.73m\^2 or \> 70 mL/min/1.73m\^2. * Patients with a treated acute rejection episode within the last 3 months. * Patients with a platelet count of \< 50,000/mm\^3 or with a white blood cell count of ≤ 2,500/mm\^3 or with a hemoglobin value \< 8 g/dL. * Presence of severe hypercholesterolemia (≥ 8.0 mmol/L) or hypertriglyceridemia (≥ 6.0 mmol/L) despite conventional lipid lowering treatment. * Patients currently treated or who have been treated with a mammalian target of rapamycin (mTOR) inhibitor. * Patients who have received an investigational drug within 4 weeks. * Patients who are human immunodeficiency virus positive or who have a current severe systemic infection requiring continued therapy according to investigator judgment. * Present use of any immunosuppressive drugs other than Neoral®/Prograf®, mycophenolic acid/azathioprine (MPA/AZA), and/or steroids. * Patients with a known hypersensitivity to drugs similar to everolimus. * Symptoms of significant mental illness which, in the opinion of the investigator, may interfere with the patient's ability to comply with the protocol. History of drug or alcohol abuse within 1 year of baseline. * Inability to cooperate or communicate with the investigator. * Patients with any past (within the last 5 years) or present malignancy other than excised squamous or basal cell carcinoma. * Females of childbearing potential that are planning to become pregnant, who are pregnant and/or lactating, or who are unwilling to use effective means of contraception. * Patients with a planned coronary revascularization or patients who have experienced a major adverse cardiovascular event (MACE) within the last 3 months.