"Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat

Inclusion Criteria: * generally healthy * not pregnant or nursing * using adequate contraception * between 18 and 50 years of age * BMI between 30 and 35 kg/m2 Exclusion Criteria: * significant renal, cardiac, liver, lung or neurological disease * high blood pressure * diabetes * prior use of thiazolidinedione * prior use of beta-blockers alcohol or drug abuse * history of thrombophlebitis, vascular or blood clotting disorders * unwilling or unable to abstain from caffeinated beverages and alcohol prior to adipose tissue biopsy and metabolic rates measurements * increased liver function test at baseline * have metal objects that would interfere with the measurement of the body composition * use drugs known to affect lipid metabolism, energy metabolism or body weight * use herbal supplements containing ephedrine and/or caffeine * take chronic medication, except hormone replacement or contraception * are a woman unwilling to use effective contraception during the trial * have heart disease or history of stroke * have urinary symptoms from enlarged prostate * have gained and or lost more than 10 pounds in the last 6 month * have use a monoamine oxidase inhibitor medication in the last month * have high or low thyroid function that has not been controlled in the normal range for at least 2 months