Patients scheduled for a tonsillectomy need postoperative pain treatment. Some of the most widely used postoperative analgetics (NSAIDs) sometimes cause rebleeding in the postoperative period, and another often used analgetic, morphine, causes nausea and vomiting. The researchers therefore will investigate new combinations of postoperative analgesics in hopes of improving pain and the need for opioids during the postoperative period.
We will investigate the effect of paracetamol versus paracetamol combined with pregabalin versus paracetamol combined with pregabalin and dexamethasone on pain and morphine requirements in the first 24 hours postoperatively. Outcomes include amount of morphine and ketobemidone used, and pain measured on a VAS scale. Side-effects, e.g., PONV, dizziness and sedation are also measured.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
147
Comparing the analgesic effect of combinations of paracetamol + placebo + placebo
Comparing the analgesic effect of combinations of paracetamol + pregabalin 300 mg + placebo
Comparing the analgesic effect of combinations of paracetamol + pregabalin 300 mg + dexamethasone 8 mg
Department of Day Case Surgery at Glostrup University Hospital
Glostrup Municipality, Denmark
Pain score (VAS) 2, 4, and 24 hours postoperatively.
Time frame: 0-24 hours
Both at rest and when swallowing 50 ml of water.
Time frame: 0-24 hours
Total amount of morphine and ketobemidone used 0-24 hours postoperatively.
Time frame: 0-24 hours
Nausea and vomiting 2, 4, and 24 hours postoperatively.
Time frame: 0-24 hours
Dizziness and sedation 2, 4, and 24 hours postoperatively.
Time frame: 0-24 hours
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