Barrier Function and Production of Inflammatory Cytokines in the Rectal Mucosa in Patients With Septic Shock

Herlev Hospital30 enrolled

Overview

Life-threatening infection impairs bloodflow to the gut, thereby causing less delivery of oxygen. This leads to increased formation of different inflammatory and infectious markers. The investigators hypothesize, therefore, that there is a significant difference in the concentrations of inflammatory and infectious markers in the rectal mucosa between patients with septic shock and healthy controls.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Septic Shock

Interventions

Rectal biopsyPROCEDURE

Rectal biopsy.

Measurement of inflammatory markers in the rectal mucosaPROCEDURE

IL-6, TNF-alfa.

Measurement of rectal lactic acidPROCEDURE

Equilibrium dialysis.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Septic shock Exclusion Criteria: * Age \< 18 years * No next of kin * Pathology of the descending or sigmoid colon or rectum * Pregnancy * 1st degree relatives with inflammatory bowel disease * Severe coagulopathy

Locations (1)

Dept. of Intensive Care 4131

Copenhagen, Denmark

Central Contacts

Michael Ibsen, MD

CONTACT

+ 45 45 35 94 18 micibs@dadlnet.dk

Anders Perner, MD, PhD

CONTACT

+ 45 45 35 41 31 ap@dadlnet.dk

Data from ClinicalTrials.gov

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