Anti Ischemic Effects of Abciximab in Angioplasty and Stenting Patients

Emory University220 enrolled

Overview

AIR STUDY TITLE: Anti-Ischemic effects of Abciximab(Reopro) PATIENT POPULATION: Patients undergoing PCI(an interventional procedure placing a small stent/metallic tube to keep a narrowed artery in your heart open) and either on a stable statin dose or not on a statin. Statin= cholesterol lowering drug(ie, lipitor, zocor). INTERVENTION: Heparin vs. heparin + abciximab during PCI PURPOSE: Measure the effects of abciximab on special healing blood stem cells (EPC's-Endothelial Progenitor Cells), on inflammation, on oxidative stress and on microvascular blood flow. PATIENT ASSESSMENT: 1. 50ccs blood draw on day 1(from sheath), day 2 ,day 7 and day 28. 2. Measurement of blood flow in selected suitable patients 3. 10 minute questionnaire before discharge and on visit on day 28.

Study Type

OBSERVATIONAL

Enrollment

220

Conditions

Coronary Artery Disease

Interventions

AbciximabDRUG

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: 1. Have either: * clinical history of anginal symptoms or positive stress test or * in stent restenosis 2. Have an angiographic \>70% coronary artery stenosis that will be treated with coronary angioplasty or stenting procedure 3. For at least four weeks prior to the procedure have been on, no Hmgcoa- reductase inhibitor or a stable statin dose 4. negative pregnancy test 5. are able to give informed consent Exclusion Criteria: 1. Coronary intervention within four weeks prior to enrollment. 2. Treatment with abciximab antagonist within four weeks. 3. treatment with thrombolytic therapy within 48 hours 4. MI within 2 months. 5. recent infections 6. general anesthesia within 3 months. 7. renal failure

Locations (2)

Atlanta VA Medical Center

Atlanta, Georgia, United States

Emory University Hospital

Atlanta, Georgia, United States