Prevalence of Salivary Hypofunction in Patients With Globus Pharyngeus

Samsung Medical Center340 enrolled

Overview

It is well known that 'globus sensation in throat' is caused by the chronic irritation and inflammation of oral, pharyngeal, or laryngeal mucosa, such as laryngopharyngeal reflux and chronic postnasal drip. Xerostomia and pharyngoxerosis due to salivary hypofunction also proved to induce the mucosal change of the oral cavity and pharynx. However, no previous studies have documented the prevalence of salivary hypofunction in patients with globus pharyngeus. Through this clinical investigation, we hypothesized that the salivary hypofunction might be one of the leading cause of globus pharyngeus.

Subjects: patients with symptoms of globus pharyngeus Globus symptom scoring: 0(mild) to 5(severe) Subjective symptom analysis by "Standard Table for Xerostomia and Pharyngoxerosis" Subjective physical finding analysis by "Standard Table for Xerostomia and Pharyngoxerosis" Objective analysis of Salivary function by 99m-Tc Salivary scintigraphy --\> Define the prevalence of salivary hypofunction in patients with globus pharyngeus (Primary end point) Subsequent analysis (Secondary end point) 1. Group 1: Globus patients with objective salivary hypofunction 2. Group 2: Globus patients with normal salivary function Intervention: Active management for xerostomia (Moisturizing, Gargling, Humidification, Massage of salivary gland, Stimulant of salivary secretion, Artificial saliva) Evaluation of the change of globus symptoms after active management of xerostomia between the Group 1 and Group 2 (at 1 months, at 3 months after the initiation of intervention)

Study Type

OBSERVATIONAL

Enrollment

340

Conditions

Globus Pharyngeus

Interventions

Conservative management for xerostomiaBEHAVIORAL

Active hydration (drinking more than 10 cups of water per day), Humidification, Oral gargle with a diluted (0.05% to 0.1%) chlorhexidine solution, Sugarless chewing gum, Saliva-stimulating sour juice (sugarless orange juice), Commercial artificial saliva, Nasal saline spray 3 to 4 times a day, Warm massage of the 4 major salivary glands.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Subjects with globus pharyngeus symptoms Exclusion Criteria: * Subjects with tumors in oral cavity, oropharynx, nasopharynx, hypopharynx, which may cause globus symptoms * subjects, who do not undergo the endoscopic exam for the upper aerodigestive tract including oral cavity, oropharynx, nasopharynx, hypopharynx. * subjects, who take medications that may have potential effect on the mucosa of the upper aerodigestive tract including oral cavity, oropharynx, nasopharynx, hypopharynx. * subjects with poor medical performance (\<70%)

Locations (1)

Samsung Medical Center

Seoul, Seoul, South Korea

Data from ClinicalTrials.gov

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