Mifepristone Versus Laminaria for Cervical Ripening in Midtrimester Induction

Dartmouth-Hitchcock Medical Center72 enrolled

Overview

Data from other countries have suggested that oral mifepristone used as a cervical ripening agent may decrease induction to delivery time in midtrimester inductions. To our knowledge, there are no trials comparing mifepristone to laminaria in a standard clinical setting with standardized misoprostol induction protocol to examine the issue of induction to delivery time. We hypothesize that mifepristone will work at least as well as laminaria for midtrimester cervical ripening prior to induction of labor with misoprostol.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Abortion, Induced

Interventions

mifepristoneDRUG

Eligibility

Sex: FEMALEMin age: 16 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * pregnant women with fetal anomalies, aneuploidy, or demise at 15-22 weeks gestation * age greater than 16 * able to speak English Exclusion Criteria: * prior uterine scar or * allergy or history of bad reaction to any of the study drugs or * history of chronic adrenal failure or * porphyria or * concurrent long-term corticosteroid treatment

Locations (1)

Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, United States

Outcomes

Primary Outcomes

induction to delivery time

Secondary Outcomes

pain

delivery within 24 hours

need for post-partum D&C

adverse events

Data from ClinicalTrials.gov

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