This is a 105-week clinical study in patients with heterozygous familial hypercholesterolemia on intensive Low Density Lipoprotein-cholesterol (LDL-C) lowering therapy intended to assess the affects of MK0524A on carotid intima media thickening using ultrasound compared to patients taking placebo. There will be 12 scheduled clinic visits involving review of medical history, physical exam, vital signs, laboratory testing, ultrasound imaging, and electrocardiograms.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
937
niacin (+) laropiprant (2 g) po qd.
niacin (+) laropiprant (2 g) placebo po qd.
Change in Mean Carotid Intima Media Thickness
change in mean carotid intima media thickness defined as a composite measure of the left and right common, bulb, and internal carotid artery.
Time frame: after 96 weeks of postrandomization treatment
Change in Lipid Profile
Time frame: after 96 weeks of postrandomization treatment
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