Treatment of Patients With Relapsed or Primary Refractory Aggressive B- Cell NHL

Inclusion Criteria: * Histologically proven high grade B-NHL (CD 20 \>= 20 % positive) * Age \>= 18 years * At least one pretreatment with anthracycline polychemotherapy +/- radiatio: * first relapse nad contraindication for aggressive salvage therapy e.g. high dose therapy with autologous stem cell transplantation * second relapse (after aggressive salvage therapy) * patient's refusal of aggressive salvage therapy in first relapse * informed consent Exclusion Criteria: * untreated patients * pretreatment with bendamustine * primary CNS- lymphoma * Karnofsky index \< 50 (except caused by lymphoma) * HIV positive, hepatitis B or C * serious concurrent disease * non-compensated heart failure (\>=NYHA 3) * non-compensated hypertension * renal insufficiency (creatinine \> 2.0 mg/dl), not related to lymphoma * hepatic insufficiency with transaminase values greater than 3-fold of normal values and/or bilirubin levels \> 200 µmol/l, not related to lymphoma * missing compliance respective incapability to comply (e.g.cerebral dysfunction * pregnancy * hematopoetic insufficiency not lymphoma related (leucocyte count \<= 2500/µl, granulocyte count \<= 1000/µl, platelet count \<= 80000/µl)