Comparison of Side Effects of Morphine and Hydromorphone Patient-Controlled Analgesia (PCA)

Columbia University50 enrolled

Overview

Both morphine and hydromorphone are pain medications commonly used after surgery. It is thought at the institution that hydromorphone causes less side effects but this has not been studied. The study proposes to treat the patients with either morphine or hydromorphone and determine how much nausea, vomiting, and itching they have with each drug

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Post Operative Pain

Interventions

Morphine PCADRUG

Morphine 1mg/mL, dose 1mL, lockout 6 minutes, max 10mL

Hydromorphone PCADRUG

hydromorphone PCA 0.2mg/lml, dose 1ml, lockout 6min, max 10ml

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients scheduled for abdominal surgery requiring post-operative PCA * ASA = I or II Exclusion Criteria: * preoperative pain or use of pain medication * narcotic allergy * morbid obesity (Body Mass Index \> 30) * diagnosis of sleep apnea * hepatic or renal disease * use of medications that would affect narcotic pharmacodynamics * preoperative nausea, vomiting, or pruritis * diagnosis of alcoholism

Locations (1)

Columbia Presbyterian Hospital

New York, New York, United States