Double Blind Randomized Study Into the Efficacy of Codeine Phosphate Analgesia After Cleft Palate Repair in Infants

Institute of Child Health44 enrolled

Overview

This study examines the analgesic efficacy of codeine phosphate. It is compared to placebo in infants receiving morphine after surgery. Codeine may be effective enough to make morphine unnecessary.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

DOUBLE

Enrollment

Conditions

Cleft Palate Repair

Interventions

Codeine Phosphate AnalgesiaDRUG

Eligibility

Sex: ALLMin age: 4 MonthsMax age: 8 MonthsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Infants with cleft palate

Locations (1)

Great Ormond Street Hospital, Anaesthetics

London, United Kingdom

Outcomes

Primary Outcomes

Dose of morphine used within the first 6h after surgery

Secondary Outcomes

Pain scores

Data from ClinicalTrials.gov

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