A Study to Evaluate the Safety and Efficacy of an Investigational Drug in the Treatment of Postoperative Dental Pain (MK-2295-005)

Merck Sharp & Dohme LLC89 enrolled

Overview

This study is being conducted to evaluate the safety and tolerability of the drug and to evaluate its efficacy compared to placebo and to ibuprofen in the treatment of postoperative dental pain in male patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Pain, Postoperative Tooth Extraction

Interventions

MK2295DRUG

Eligibility

Sex: MALEMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients in generally good health who are scheduled to have two or more third molars removed, at least one of which is partially or completely embedded in bone and is a mandibular impaction Exclusion Criteria: * Patient has a temperature of 37.5C or greater prior to dosing * Patient has participated in another clinical study within the last 4 weeks

Outcomes

Primary Outcomes

Peak analgesic response, safety, and tolerability

Time frame: Over 24 Hours

Secondary Outcomes

Onset of analgesia, duration of analgesia

Time frame: Over 24 Hours

Data from ClinicalTrials.gov

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