Study Evaluating IV Methylnaltrexone for the Treatment of Post Operative Ileus

Inclusion: * Must be scheduled for a segmental colectomy via open laparotomy with general anesthesia * Subjects with history of inflammatory bowel disease are eligible as long as the disease is not currently active and all other criteria are met * Subjects must meet the American Society of Anesthesiologists physical status I, II or III Exclusion: * Subjects who are scheduled for laparoscopic surgery for the segmental colectomy * Subjects with a recent history (\<1 year prior to randomization) of abdominal radiation therapy; Subjects with a history of small bowel obstruction, known or suspected bowel adhesions (other than minor, clinically nonsignificant adhesions) * Subjects undergoing operations resulting in gastrointestinal ostomies, or who require use of post operative nonsteroidal anti-inflammatory drugs (NSAIDs)