The purpose of this clinical trial is to prove the efficacy of the following new regimen treatment: * Administration of anti-CD20 (Rituximab) combined with chemotherapy. * Combined treatment with high doses of methotrexate and high doses of cytarabine with conventional cytostatics (block C) * Prophylactic administration of G-CSF after all chemotherapy cycles * local irradiation after 6 cycle if CNS was affected or if there are residual tumour
Clinical Trial with a pharmaceutical speciality in new conditions to use.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
20
375 mg/m2/d day 1
Hospital General de Alicante
Alicante, Alicante, Spain
Hospital "Santa Creu i Sant Pau"
Barcelona, Barcelona, Spain
Hospital Clínico y Provincial de Barcelona
Barcelona, Barcelona, Spain
Determinate the efficacy of the administration of anti-CD20 (RITUXIMAB) combined with chemotherapy.
Time frame: 1 year
Combined treatment with high doses of methotrexate and high doses of cytarabine with conventional cytostatics (block C)
Time frame: 1 year
Prophylactic administration of G-CSF after all chemotherapy cycles
Time frame: 1 year
local irradiation after 6 cycle if CNS was affected or if there are residual tumour
Time frame: 1 year
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Hospital Juan Canalejo
A Coruña, La Coruña, Spain
Hospital Clínico San Carlos de Madrid
Madrid, Madrid, Spain
Hospital Doce de Octubre
Madrid, Madrid, Spain
Hospital Universitario Morales Meseguer, Murcia
Murcia, Murcia, Spain
Hospital Carlos Haya
Málaga, Málaga, Spain
Hospital Son Dureta
Palma de Mallorca, Palma de Mallorca, Spain
Hospital Universitario Virgen del Rocío
Seville, Sevilla, Spain
...and 5 more locations