Safety and Efficacy Study Comparing Thrombin for Arterial Sealing

Inclusion Criteria: * The subject is 18 years of age or older * The subject is undergoing a diagnostic or interventional endovascular procedure via a retrograde femoral arterial access * The subject is willing and able to provide appropriate informed consent * The subject is willing and able to comply with the requirements of the study protocol, including the predefined follow-up evaluations Exclusion Criteria: Exclusion criteria determined prior to procedure: * The subject has a history of clinically severe peripheral vascular disease documented as any of the following: * Severe claudication (walking \< 100 feet) * Absent pulses in the affected limb * ABI \< 0.5 at rest * Known diameter stenosis ≥ 50% in the iliac or femoral artery on the affected side * Prior vascular bypass surgery involving the affected femoral artery * Prior stent placement in the vicinity of the arterial puncture site * The subject is known to be, or suspected to be, pregnant (verified in a manner consistent with institution's standard of care), or is lactating * The subject has a pre-existing severe non-cardiac systemic disease or pre-existing terminal illness * The subject has had an acute myocardial infarction ≤ 72 hours before the catheterization procedure * The subject is unable to ambulate at baseline * The subject is known to require an extended hospitalization (e.g., subject is undergoing CABG surgery) * The subject has a known bleeding disorder (including thrombocytopenia \[\< 100,000 platelet count\], thrombobasthenia, hemophilia, or von Willebrand disease) * The subject is receiving Coumadin/warfarin therapy and has an INR \> 2.0 on the day of, or the day before the study procedure. (INR of \> 2.0 should not result in a dose change prior to the study procedure. If dosage changed, test should be repeated prior to the procedure) * The subject has a known allergy to bovine derived products or any other materials used in the Diagnostic Duett Pro Sealing Device * The subject has undergone prior use of a closure device in the ipsilateral common femoral artery ≤ 6 months before the current catheterization procedure * The subject has undergone prior use of manual compression for closure in the ipsilateral common femoral artery ≤ 6 weeks before the current catheterization procedure * The subject has undergone current, recent, or prior use of an intra-aortic balloon pump through the existing arterial puncture site * The subject is unavailable for follow-up * The subject is currently participating in another investigational device or drug trial * The subject has previously participated in this trial (Protocol 0106) Exclusion criteria to be determined during the procedure: * The subject has an antegrade puncture * The subject's arterial introducer sheath is \<5F or \> 9F or longer than 15.2 cm in overall length * The subject has a suspected posterior femoral arterial wall puncture or puncture distal to the common femoral artery bifurcation * The subject's common femoral artery diameter is estimated to be \< 6 mm via angiogram * The subject has tortuous vascular anatomy with greater than 90o bends on femoral angiogram * The subject is severely hypertensive (defined as systolic BP \> 180 mmHg or diastolic BP \> 110 mmHg) * The subject has experienced hemodynamic instability, defined as systolic blood pressure \< 90 mmHg or cardiogenic shock, during or immediately post-procedure * The subject has been anticoagulated with unfractionated heparin and has an ACT of \> 300 seconds at completion of the antecedent procedure * The subject is anticipated to continue dosing of heparin or anti-coagulant therapy (except any approved GPIIb/IIIa platelet receptor blocker) ≤ 6 hours following completion of the interventional or diagnostic procedure * The subject has received thrombolytic therapy (e.g., streptokinase, urokinase, or t-PA) ≤ 24 hours prior to the catheterization procedure * The subject has a large hematoma (≥ 6cm in diameter) present prior to vascular sealing.