Safety Study of MVA Smallpox Vaccine in Subjects With a History of Atopic Dermatitis (AD)

Inclusion Criteria: * Adults at least 18 years old and who were born after 1971 with no previous history of smallpox vaccination * Subjects must be in good general health Female subjects must not be pregnant or lactating and must agree to practice birth control during the course of the study * Subjects must have a diagnosis of AD by an experienced clinician that includes a history of both major and minor diagnostic criteria * At the time of screening, the subject must have "mild to moderate" AD. Exclusion Criteria: * History or evidence of prior exposure to a vaccinia or MVA- containing product * known or suspected history of immunodeficiency other than AD * Known or suspected impairment of major organ function * Known history or diagnosis of cardiac disease or cerebrovascular disease * presence of acute, chronic, or active exfoliative skin conditions other than AD, open wounds, or burns. * Dementia or history of seizures * Known allergies to MVA or any known components of the vaccine * transfusion of blood, organ transplantation, or treatment with any blood product * morbid obesity, or a BMI less than or equal to 18.5 * history of or current drug or alcohol abuse (except nicotine) within the past 6 months or any history of IV drug use * history of major psychiatric illness except major depression not requiring medical therapy. * subjects who have participated in another investigational drug or vaccine trial within 30 days of study day 0