Fludarabine and Cyclophosphamide Followed By LMB-2 Immunotoxin in Treating Patients With Hodgkin's Lymphoma

National Institutes of Health Clinical Center (CC)

Overview

RATIONALE: Drugs used in chemotherapy, such as fludarabine and cyclophosphamide, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. LMB-2 immunotoxin can find cancer cells and kill them without harming normal cells. Giving fludarabine and cyclophosphamide followed by LMB-2 immunotoxin may kill more cancer cells. PURPOSE: This clinical trial is studying how well giving fludarabine and cyclophosphamide followed by LMB-2 immunotoxin works in treating patients with Hodgkin's lymphoma.

OBJECTIVES: Primary * Determine the feasibility of pretreatment with fludarabine phosphate and cyclophosphamide in preventing neutralization of antibodies in patients with CD25-positive Hodgkin's lymphoma. Secondary * Determine the response rate in patients treated with LMB-2 immunotoxin. * Determine the response duration in patients receiving this treatment. * Correlate serum levels of LMB-2 immunotoxin with toxicity and response in these patients. * Assess the development of neutralizing antibodies and the effect of these antibodies on blood levels of LMB-2 immunotoxin and toxicity. * Correlate soluble Tac-peptide levels with treatment response in these patients. OUTLINE: This is a nonrandomized, pilot study. Patients receive fludarabine phosphate IV over 30 minutes and cyclophosphamide IV over 60 minutes on days 1-4 and filgrastim (G-CSF) subcutaneously once daily beginning on day 5 and continuing until blood counts recover. Beginning 4 weeks after completion of chemotherapy, patients receive LMB-2 immunotoxin IV over 30 minutes on days 1, 3, and 5. Treatment repeats every 28 days for up to 6 courses in the absence of disease progression. Blood is obtained prior to and after chemotherapy and then periodically during LMB-2 immunotoxin therapy for pharmacokinetic studies to measure lymphocyte subsets. PROJECTED ACCRUAL: A total of 30 patients will be accrued for this study.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Conditions

Lymphoma

Interventions

LMB-2 immunotoxinBIOLOGICAL

cyclophosphamideDRUG

fludarabine phosphateDRUG

pharmacological studyOTHER

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

DISEASE CHARACTERISTICS: * Histopathologically confirmed CD25+ Hodgkin's lymphoma * At least 20% of the malignant cells positive by immunohistochemistry * Stage II-IV disease * Meets the following criteria: * Failed standard chemotherapy * Not eligible for curative salvage radiotherapy or chemotherapy * Not eligible for or refused bone marrow transplantation * Measurable disease * No patient whose serum neutralizes LMB-2 immunotoxin in tissue culture, due either to antitoxin or antimouse-IgG antibodies * No patient whose serum neutralizes \> 75% of the activity of 1 µg/mL of LMB-2 immunotoxin PATIENT CHARACTERISTICS: * ECOG performance status 0-2 * Absolute neutrophil count ≥ 1,000/mm³ * Platelet count ≥ 50,000/mm³ * Not pregnant or nursing * Negative pregnancy test * Fertile patients must use effective contraception * ALT and AST ≤ 2.5 times upper limit of normal * Albumin ≥ 3.0 g/dL * Bilirubin ≤ 2.2 mg/dL (\< 5 mg/dL if Gilbert's syndrome is present) * Creatinine ≤ 1.4 mg/dL OR creatinine clearance ≥ 50 mL/min * No uncontrolled intercurrent illness including, but not limited to, any of the following: * Ongoing or active infection * Symptomatic congestive heart failure * Unstable angina pectoris * Cardiac arrhythmia * Psychiatric illness or social situations that would limit study compliance * No HIV or hepatitis C positivity * Hepatitis B surface antigen positivity allowed provided patient is receiving lamivudine * LVEF ≥ 45% * DLCO ≥ 50% of normal OR FEV\_1 ≥ 60% of normal * No active second malignancy requiring treatment PRIOR CONCURRENT THERAPY: * See Disease Characteristics * No systemic cytotoxic chemotherapy within the past 4 weeks * No systemic steroids (except stable doses of prednisone ≤ 20 mg/day) within the past 4 weeks * No monoclonal antibody therapy within the past 12 weeks * No prior LMB-2 immunotoxin * No concurrent warfarin

Locations (1)

Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office

Bethesda, Maryland, United States

Outcomes

Primary Outcomes

Feasibility of using fludarabine phosphate and cyclophosphamide to decrease neutralizing antibodies

Secondary Outcomes

Response rate

Response duration

Correlation of serum levels of LMB-2 immunotoxin with toxicity and response

Development of neutralizing antibodies and its effect on blood level of LMB-2 immunotoxin and toxicity

Correlation of soluble Tac-peptide with treatment response

Data from ClinicalTrials.gov

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