Modification of Posttetanic Count (PTC) for Monitoring Deep Neuromuscular Block II

Rigshospitalet, Denmark45 enrolled

Overview

The purpose of this study is to examine the relationship between post-tetanic count (PTC) and time to first response to Train of four (TOF) stimulation during deep neuromuscular blockade induced by rocuronium.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Neuromuscular Blockade

Interventions

Post-tetanic count frequencyPROCEDURE

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA 1-3 * General anaesthesia \>1 hour * Surgery in supine position with possibility of monitoring the neuromuscular blockade at the thumb (n.ulnaris stimulation). * Written informed content Exclusion Criteria: * Neuromuscular disorders, hepatic and renal dysfunction * Medication expected to interfere with the neuromuscular blocking agent * Allergy to any medication used during anaesthesia * Body weight less or exceeding 20% of the ideal body weight * Pregnancy or breastfeeding

Locations (2)

Dep. of Anesthesia, Rigshospitalet

Copenhagen, Copenhagen, Denmark

Dep. of Anesthesia, Herlev hospital

Herlev, Herlev, Denmark

Outcomes

Primary Outcomes

Time to first response to TOF stimulation (T1)

Secondary Outcomes

Time to second response to TOF stimulation (T2)

Time to first post-tetanic count (PTC)

Number of post-tetanic count at first response to TOF

Time to T1=25%

Interval 25-75%

Time to TOF 0.9

Time to TOF 1.0

Data from ClinicalTrials.gov

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