Treatment of Adult Ph+ LAL With BMS-354825

Inclusion Criteria: * Patients with Ph+ and/or BCR/ABL+ ALL * Age ≥18 years old * De novo ALL (within 14 days from diagnosis) * No prior treatment with any anti-leukemic drugs with the exception of steroids for no more than 14 days (including the 7-day pretreatment already scheduled in the protocol) * WHO performance status ≤2 * Absence of central nervous system (CNS) leukemia * Normal serum level of potassium, total calcium corrected for serum albumin magnesium and phosphorus, or correctable with supplements * ALT and AST ≤2.5 x ULN or ≤5.0 x ULN if considered due to leukemia * Alkaline phosphatase ≤2.5 x ULN unless considered to leukemia * Serum bilirubin ≤2 x ULN * Serum creatinine ≤3 x ULN * Serum amylase ≤1.5 x ULN and serum lipase ≤1.5 x ULN * Normal cardiac function * Written informed consent prior to any study procedures being performed. Exclusion Criteria: * Impaired cardiac function, including any one of the following: * Impairment of gastrointestinal (GI) function or GI disease that may significantly alter the absorption of BMS-354825 (e.g., ulcerative diseases, uncontrolled nausea, vomiting, diarrhoea, malabsorption syndrome, or small bowel resection) * Use of therapeutic warfarin * Acute or chronic liver or renal disease considered unrelated to leukemia * Other concurrent severe and/or uncontrolled medical conditions (e.g., uncontrolled diabetes, active or uncontrolled infection) that could cause unacceptable safety risks or compromise compliance with the protocol * Treatment with any hematopoietic colony-stimulating growth factors (e.g., G-CSF, GM¬CSF) ≤1 week prior to starting study drug * Patients who are currently receiving treatment with any of the medications listed in "Appendix F" and the treatment cannot be either discontinued or switched to a different medication prior to starting study drug. The medications listed in "Appendix F" have the potential to prolong the QT interval. * Patients who have received any anti-leukemic agents and treatments including steroids for more than 14 days including 7 days pretreatment that is part of the protocol * Patients who have received any investigational drug in the last 2 weeks * Patients who have undergone major surgery ≤2 weeks prior to starting study drug or who have not recovered from side effects of such therapy * Patients who are pregnant or breast feeding, or adults of reproductive potential not employing an effective method of birth control. (Women of childbearing potential must have a negative serum pregnancy test within 48 hrs prior to administration of BMS-354825). Post-menopausal women must be amenorrheic for at least 12 months to be considered of non-childbearing potential. Male and female patients must agree to employ an effective barrier method of birth control throughout the study and for up to 3 months following discontinuation of study drug * Known diagnosis of human immunodeficiency virus (HIV) infection (HIV testing is not mandatory) * Patients with a history of another primary malignancy that is currently clinically significant or currently requires active intervention * Non compliant to oral medication patients.