Penetrance of Third Generation Fluoroquinolones in Eyes With Functioning Filtering Blebs

Indiana University School of Medicine48 enrolled

Overview

Based on previous results with eyes without filtering blebs, the aqueous concentrations of ofloxacin and levofloxacin will exceed the concentration of ciprofloxacin after either topical or topical plus oral administration.

The purpose of this study is to assay human aqueous for concentrations of ofloxacin, ciprofloxacin and levofloxacin after topical or combined topical and oral administration in eyes with filtering blebs.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Cataract

Interventions

Ofloxacin 0.3%DRUG

Ciprofloxacin 0.3%DRUG

Levofloxacin 0.5%DRUG

Ofloxacin 400mgDRUG

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * All patients with functioning filtering blebs will be evaluated prospectively for inclusion Exclusion Criteria: * Any subject who is already scheduled to have cataract surgery performed will qualify for participation with the exception of the following exclusion criteria: * Ongoing ocular inflammatory disease * Bleb leakage - determined by Seidel test * Suspected infection * Known contraindications to use of any of these study medications. * Pregnancy

Locations (3)

Indiana University Hospital

Indianapolis, Indiana, United States

Richard L Rodeboush VA Medical Center

Indianapolis, Indiana, United States

Wishard Memorial Hospital

Indianapolis, Indiana, United States

Outcomes

Primary Outcomes

Aqueous levels of antibiotics

Data from ClinicalTrials.gov

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