Bangladesh Vitamin E and Selenium Trial

University of Chicago7,000 enrolled

Overview

The purpose of this study is to evaluate whether selenium and/or vitamin E are effective in preventing non-melanoma skin cancers.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

7,000

Conditions

Non-melanoma Skin Cancer

Interventions

SeleniumDIETARY_SUPPLEMENT

200 ug Selenium daily

vitamin EDIETARY_SUPPLEMENT

100 mg Vitamin E daily

Eligibility

Sex: ALLMin age: 25 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Manifest arsenic skin lesions (melanosis, leucomelanosis, or keratosis) * Aged 25 to 65 years * Permanent resident of study area Exclusion Criteria: * Pregnancy * Clinically too ill (enlarged spleen or liver) * Presence of gangrene * Cancer

Locations (2)

Columbia University Arsenic Research Project

Dhaka, Bangladesh

ICDDR,B

Dhaka, Bangladesh

Outcomes

Primary Outcomes

Skin Cancer

Time frame: Incidence during the 6-year study period

Secondary Outcomes

Mortality

Time frame: Occurrence during the 6-year study period

Diabetes

Time frame: Incidence within 6-year study period

Data from ClinicalTrials.gov

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