A Randomized, Control Trial for Preinduction Cervical Ripening

The University of Texas Health Science Center, Houston540 enrolled

Overview

The goal of this study is to compare the vaginal delivery rates in women undergoing induction of labor with an unripe cervix between oxytocin induction alone and preinduction cervical ripening with prostaglandin El (misoprostol). Secondary goals are to measure and compare the time intervals to delivery between the two methods.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

540

Conditions

Labor, Induced

Interventions

MisoprostolDRUG

oxytocinDRUG

Eligibility

Sex: FEMALE

Medical Language ↔ Plain English

Inclusion Criteria: * Women that are hospitalized for induction of labor that have a Bishop's score \<5 * singleton gestation * cephalic presentation * 24 weeks gestational age Exclusion Criteria: * Prior uterine surgery * malpresentation * placenta previa or abruption * clinically suspected or diagnosed intra amniotic infection * genital HSV infection * multiple gestation * premature rupture of the membranes * active labor * maternal/fetal conditions that may preclude labor induction in the opinion of the investigators

Locations (1)

Lyndon B. Johnson Hospital

Houston, Texas, United States

Outcomes

Primary Outcomes

Vaginal Delivery rates

Secondary Outcomes

Time interval to delivery

Data from ClinicalTrials.gov

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