Multiple Dose Study of MPC-6827 in Subjects With Refractory Brain Metastases

Inclusion Criteria: * Refractory Brain Metastases * At least 1 measurable intracranial lesion as defined by RECIST * ECOG less than or equal to 1 * Adequate hematology/organ function * No baseline peripheral or central neuropathy above grade 1 Exclusion Criteria: * Hypersensitivity to Cremophor EL * Pregnant or Lactating * Spinal Cord Compression * Pre-existing dementia/cognitive disfunction * Require Neupogen or Neulasta to Maintain Neutrophil Count * Have Primary Brain Cancer * Have History of Ischemic Heart Disease * Have Diabetes