Injection Site Study In Patients With Type 2 Diabetes Mellitus (T2DM) And Healthy Volunteers

Inclusion criteria: * They can be healthy volunteers or subjects with type 2 diabetes mellitus that has been diagnosed for at least three months. T2DM subjects must be taking either (1) no medication for their diabetes or (2) taking metformin or (3) taking a TZD (thiazolidinedione). * Subjects must have a BMI between 25 and 40 kg/m² and weigh at least 50kg. * Women must be of non-childbearing potential. Exclusion criteria: * Bloodwork that meets certain criteria (for example, total cholesterol \> 240 mg/dL) * Clinically significant hepatic enzyme elevation * HbA1c less than 6.5 or greater than 10 * Positive test result for Hepatitis B surface antigen, positive Hepatitis C or HIV * Any major illness other than diabetes * Previous use of insulin as treatment for diabetes * Significant renal disease as defined by screening lab tests * History of drug or other allergy which in the opinion of the investigator contradicts subject participation * Smoking or use of nicotine-containing products within the previous 6 months * History of alcohol or drug abuse * Unwilling to abstain from alcohol prior to and during the in-patient clinic stays * Unwilling to abstain from caffeine- or xanthine-containing products prior to and during the in-patient clinic stays * Use of St. John's Wort during the study * Has donated 500 nL or more blood within 56 days of dosing or plans to donate blood in the month following study participation.