Incisionless Treatment for Patients With Inadequate Weight Loss Following Roux-en-Y Gastric Bypass

Inclusion Criteria: * 6 months post primary RYGB with inadequate weight loss or weight regain * BMI \>30 and ≤ 50 * Dilated gastrojejunal anastomosis * Successfully completes screening process * Signed consent Exclusion Criteria: * Recently quit smoking or plan to quit within the next year * Pregnant or planning to become pregnant over the course of the next 9 months * Mallampati score of 4 * Serious systemic disease or active disease of the gastrointestinal tract * Gastric pouch abnormalities * Significant movement limitations * Use of weight-promoting or weight-reduction drugs during study period * Severe eating disorders * Uncontrolled depression or psychoses * Ongoing severe complication resulting from initial RYGB or other condition that in the investigators' assessment would make the patient an unsuitable candidate for the study procedure * History of significant cardiovascular, cerebrovascular or pulmonary disease * Not a candidate for conscious or general sedation * Anticoagulant therapies * Active substance abuse * Life expectancy \< 1 year * Enrolled in another investigational drug or device trial that has not completed the primary endpoint or that clinically interferes with this trial's study endpoints