Labetalol to Prevent Hypertension and Tachycardia During Fiberoptic Bronchoscopy

Rabin Medical Center72 enrolled

Overview

Passing a bronchoscope through the airways frequently causes a stress response even though patients are sedated. This stress response is usually an increase in pulse and blood pressure, which may have undesirable effects on the heart and circulation. We plan to give patients labetalol (a beta blocker which reduces pulse and blood pressure) in addition to normal sedation, to patients undergoing bronchoscopy in our department.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Bronchoscopy

Interventions

Labetalol 10mg ivDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All patients over 18 years old undergo fiberoptic bronchoscopy in our unit Exclusion Criteria: * inability or refusal to give informed consent * bronchoscopy through an artificial airway * intolerance or allergy to the study drug * bradycardia (HR\<60/min) or hypotension (systolic BP \<100) at screening * pregnancy, * concomitant treatment with diltiazem or verapamil * intention to use propofol as the sedative agent for bronchoscopy.

Locations (1)

Rabin Medical Center

Petah Tikva, Israel

Outcomes

Primary Outcomes

Heart Rate

Systolic Blood Pressure

Diastolic Blood Pressure

Rate pressure product (HR*SBP/100)

Data from ClinicalTrials.gov

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