Improving Metabolism With HDL Cholesterol

Bayside Health13 enrolled

Overview

High levels of good cholesterol (HDL) in our blood decreases our chance of having a heart attack. This relates in part to the role good cholesterol plays in reducing build up of fat in the arteries. However, good cholesterol has many other protective effects. We have recently identified three enzymes (proteins) activated by HDL in cells lining the blood vessels, which may be responsible for some of HDL's protective actions.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Heart Disease Diabetes

Interventions

rHDLDRUG

Eligibility

Sex: MALEMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Aged 18 - 65 years * Free of overt coronary disease * Body mass index \<35 kg.m-2 * Fasting plasma glucose \> 7 mmol/L-1 * No major illness Exclusion Criteria: * Unable to give informed consent * Smokers * Abnormal LFT, U\&E, FBE or creatinine

Locations (1)

Alfred Hospital

Melbourne, Victoria, Australia

Outcomes

Primary Outcomes

Metabolic parameters

Data from ClinicalTrials.gov

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