This mechanistic study will evaluate the effect of vildagliptin on glucose-stimulated insulin secretion to improve the incretin effect in patients with type 2 diabetes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
22
vildagliptin 100 mg
matching placebo
Diabetes Zentrum Bad Lauterberg
Bad Lauterberg im Harz, Germany
Novartis Pharmaceuticals
Basel, Switzerland
Change in C-peptide IAUC (0-4hr)
Time frame: 2 weeks after treatment
Change in insulin secretion rate (ISR) relative to glucose (0-2hr)
Time frame: after 2 weeks of treatment
Change in postprandial C-peptide
Time frame: after two weeks of treatment
Change in postprandial insulin
Time frame: after two weeks of treatment
Change in postprandial glucagon
Time frame: after two weeks of treatment
Change in postprandial GLP-1
Time frame: after 2 weeks of treatment
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