Efficiency of a New Therapy to Treat Stenosis of Coronary Vessels in Comparison With Two Already Admitted Therapies

Inclusion Criteria: * age: 18 to 80, males or females * stable or instable angina pectoris and or/ documented myocardial ischemia * willingness and ability to adhere to the study conditions * written informed consent after patient information * De-novo stenosis of coronary artery with a degree of stenosis between 50% and 99%, that is accessible to PTCA * Target vessels diameter of at least 2,5 mm and length of lesion below 18 mm Exclusion Criteria: * Acute myocardial infarction or still elevated CK/CK-MB after acute myocardial infarction * known severe arrhythmias that necessitate a long term antiarrhythmic therapy * pericarditis * intracardiac thrombus * Bacterial endocarditis * Cardiopulmonary reanimation with cardiac massage within the last 6 months * Thromboembolic accident within the last 6 months * Severe peripheral arterial occlusive disease, that excludes the use of a 6 French catheter or that requires a special antithrombotic or anticoagulatory regime * Manifest hyperthyreosis * Neutrohile granulocytes less than 3000/mm3 and platelets below 100.000 or above 700.000/mm3 * Renal insufficiency with serum creatinine above 1,5 mg/L * severe systemic hypertension despite antihypertensive medication * other diseases which might lead to protocol violations or reduce life expectancy * significant upper intestinal bleeding within the last 6 months * life expectancy \< 1 year * poor general condition * Premenopausal women, women who are postmenopausal less than 2 years * known allergy or hypersensitivity to Paclitaxel, to one of the TAXOL-components, to one of the stent components, to acetylsalicylic acid, heparin, clopidogrel or contrast agent * Concurrent participation or participation within the last 30 days prior to screening in another drug trial or a trial with a medical device * absence of written declaration of consent * inability, to understand sense and purpose of the study or not willing to keep the conditions of the study * Bifurcation stenosis, ostium stenosis, main stem stenosis ot the target vessel * visible thrombus in target vessel * Severely curved or sclerosed target vessel * complete closure of target vessel * Severe impairment of left ventricular function with left ventricular ejection fraction of less than 30% * Patients with expected indication for operative myocardial revascularisation within the next six months * patients with contraindication for aortocoronary bypass operation, * patients, who are principally not available for a second coronary angiography 6 months after stent implantation or who have a contraindication for a second coronary angiography