The Effect of Viral Load on Intrahepatic Recurrence in Hepatitis B Virus (HBV)-Related Hepatocellular Carcinoma (HCC)

Seoul National University Hospital145 enrolled

Overview

The purpose of this study is to evaluate the effect of serum hepatitis B virus (HBV) DNA level on intrahepatic recurrence in locally treatable hepatocellular carcinomas (HCCs) related with HBV.

Prospective cohort study Survival * Overall survival rate * Disease free survival rate Recurrence * Cumulative recurrence rate

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

145

Conditions

Carcinoma, Hepatocellular Chronic Hepatitis B

Interventions

PEITPROCEDURE

Percutaneous Ethanol Injection Therapy

RFTAPROCEDURE

Radiofrequency Thermal Ablation

Eligibility

Sex: ALLMin age: 19 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Child-Pugh Class A or B * Maximal tumor size less than 5 cm * No previous history of treatment for hepatocellular carcinoma * Recurrent hepatocellular carcinoma located more than 2 cm from the previous cancer site and is found more than 1 year's gap Exclusion Criteria: * Hepatocellular carcinoma in portal vein * Hepatocellular carcinoma in hepatic vein

Locations (1)

Seoul National University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

1,3,5 Year-Disease Free Survival (or Recurrence Free Survival)

The disease free survival is defined as the total number of surviving participants without intrahepatic recurrence of hepatocellular carcinoma for 1, 3, and 5 years.

Time frame: 1,3,5 year

Secondary Outcomes

Overall Survival

Overall Survival: Number of Participants who Died

Time frame: through study completion, an average of 3 years

Data from ClinicalTrials.gov

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