Gemcitabine Plus Albumin-bound Paclitaxel In Patients With Advanced Metastatic Pancreatic Cancer

Inclusion Criteria: * Patient has histologically or cytologically confirmed metastatic adenocarcinoma of the pancreas. Patients with islet cell neoplasms are excluded. * Male or non-pregnant and non-lactating female, and age greater or equal to 18. * If a female patient is of child-bearing potential, as evidenced by regular menstrual periods, she must have a negative serum pregnancy test beta-human chorionic gonadotropin (B-hCG) documented within 72 hours of the first administration of study drug. * If sexually active, the patient must agree to use contraception considered adequate and appropriate by the investigator. * Patient must have received no prior therapy for the treatment of metastatic disease. Prior treatment with 5-fluorouracil (5-FU) or gemcitabine administered as a radiation sensitizer during and up to 4 weeks after radiation therapy is allowed. If a patient received gemcitabine in the adjuvant setting, tumor recurrence must have occurred at least 6 months after completing the last dose of gemcitabine. * Patient has the following blood counts at baseline * Absolute neutrophil count (ANC) equal or greater to 1.5 x 10\^9/L; * Platelets equal or greater to 100 x 10\^9/L * Hemoglobin equal or greater to 9 g/dL. * Patient has the following blood chemistry levels at baseline: * Aspartate aminotransferase (SGOT), Alanine aminotransferase (SGPT) equal or less than 2.5 x upper limit of normal range (ULN) is allowed * Bilirubin less than or equal to ULN * Serum creatinine within normal limits or calculated clearance equal or greater to 60 mL/min/1.73M\^2 patients with serum creatinine levels above the institutional normal value * Patient has no clinically significant abnormalities in urinalysis results * Patient has acceptable coagulation status as indicated by a prothrombin time (PT) within normal limits (plus or minus 15%) and partial thromboplastin time (PTT) within normal limits (plus or minus 15%). * Patient has a Karnofsky performance status (KPS) greater or equal to 70 (Eastern Cooperative Oncology Group \[ECOG\] PS 0-1). * Patient has one or more metastatic tumors measurable by computed tomography (CT) scan. * Patient has been informed about the nature of study, and has agreed to participate in the study, and signed the Informed Consent form prior to participation in any study-related activities. Exclusion Criteria: * Patient has known brain metastases unless previously treated and well controlled for at least 3 months (defined as stable clinically, no edema, no steroids and stable in two scans at least 4 weeks apart). * Patient uses therapeutic coumadin for a history of pulmonary emboli and deep vein thrombosis (DVT). * Patient has active, uncontrolled bacterial, viral, or fungal infection(s) requiring systemic therapy. * Patient has known infection with human immunodeficiency virus (HIV), hepatitis B, hepatitis C. * Patient has undergone major surgery, other than diagnostic surgery i.e.-- done to obtain a biopsy for diagnosis without removal of an organ), with 4 weeks prior to Day 1 of treatment in this study. * Patient received radiotherapy, surgery, chemotherapy, or an investigational therapy within 3 weeks prior to study entry weeks (6 weeks for nitrosureas or mitomycin C). * Patient has a history of allergy or hypersensitivity to the study drug. * Patient has serious medical risk factors involving any of the major organ systems such that the investigator considers it unsafe for the patient to receive an experimental research drug. * Patient is unwilling or unable to comply with study procedures. * Patient is enrolled in any other clinical protocol or investigational trial.