hCG Supplementation in Frozen-Thawed Embryo Transfer Cycle

Hadassah Medical Organization300 enrolled

Overview

The implantation rate after frozen-thawed embryo transfer cycles depends mostly on the receptivity of the endometrium and the embryo quality.The effects of human chorionic gonadotropins (hCG) on the endometrium have been investigated for several years. hCG was shown to up-regulate gene expression during the differentiation of human endometrial stromal cells into decidua. The aim of our study was to assess the benefit of hCG supplementation throughout the secretory phase of artificial frozen-thawed embryo transfer cycles.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

300

Conditions

Fertility Agents, Female

Interventions

s.c. human chorionic gonadotropin (Ovitrelle)DRUG

S.C. Ovitrelle 250 mcg once

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * all women on frozen-thawed embryo-transfer cycle Exclusion Criteria: * any allergy to injection of human chorionic gonadotropin before

Locations (1)

Hadassah Medical center

Jerusalem, Israel

Outcomes

Primary Outcomes

implantation rate

Time frame: 4 weeks

pregnancy rate

Time frame: 4 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.